Uterine Corpus Cancer Subcommittee

Purpose
The NRG Oncology Uterine Corpus Cancer Subcommittee’s purpose is to improve the live of patients with uterine cancer by designing and conducting practice-changing multi-institutional clinical trials and translational research. This committee focuses on developing and testing innovative advanced surgical, radiation oncology, and systemic (including chemotherapy and other targeted/biologic therapies) technologies for patients with gynecologic uterine malignancies. Additionally, the committee is committed to identifying and rectifying disparities in patient outcomes within this population.

The goals of this committee include developing national and international priorities, goals, and initiatives for the management of uterine cancer; developing and managing currently active and developing NRG clinical trials on the prevention, diagnosis, and treatment of uterine corpus cancers; and, fostering the advancement of promising therapeutics in development and exploring potential translational research and biomarker development for incorporation into future clinical trials. This committee strives to develop and implement standardized procedures needed to design and conduct a research protocol within NRG while identifying potential barriers, and potential solutions to improve enrollment to NRG clinical trials in uterine corpus cancers, including fostering international collaboration. This committee meets four times a year, twice in-person and two virtual interim meetings.

Uterine Corpus Cancer Subcommittee Leadership

Chair

Matthew Powell, MD

Vice Chair

Ann Klopp, MD

Working Groups

Gestational Trophoblastic Working Group

Cf/ctDNA Working Group

Protocol 210 Working Group

Committee Members

    Core Members

    • Therese Youssef Andraos
    • Floor Backes
    • Victoria Bae-Jump
    • Emma L. Barber
    • Joyce Barlin
    • David Bender
    • Susana Campos
    • Kelley Carrick
    • Bradley R. Corr
    • Casey Cosgrove
    • Kathleen Darcy
    • Linda Duska
    • Britt Erickson
    • Ramez Eskander
    • Ashley Felix
    • Katherine Fuh
    • Neil Horowitz
    • Anuja Jhingran
    • Namita Khanna
    • Emily Ko
    • Lindsay M. Kuroki
    • Lisa M. Landrum
    • Helen J. Mackay
    • Vicky Makker
    • Cara Mathews
    • Colleen McCormick
    • David Miller
    • Amanda Nickels Fader
    • Bhavana Pothuri
    • Emma Rossi
    • Andrea Russo
    • Brian Slomovitz
    • Michael Toboni
    • Akila Viswanathan
    • Boris Winterhoff

    General Members

    • Mariam AlHilli
    • Amy Armstong
    • Jamie Bakkum-Gamez
    • Emma Barber
    • Michael E. Carney
    • Aine Clements
    • Christopher H. Chapman
    • Joshua Cohen
    • Bradley Corr
    • Janell Darby
    • Amanda Nickles Fader
    • Julia Fehniger
    • Peter Frederick
    • Marina Frimer
    • Valerie Galvan-Turner
    • Sarah Gill
    • Allison Gockley
    • Gregory Gressel
    • Michael Guy
    • Kosei Hasegawa
    • James Hoffman
    • Elizabeth Hopp
    • Krisha Howell
    • Sokbom Kang
    • Juraj Kavecansky
    • Christi Kim
    • Christine Kim
    • Min Kyu Kim
    • Katherine Kurnit
    • Olivia Lara
    • Nita Lee
    • Kimberly Leslie
    • Larry Maxwell
    • Carolyn McCourt
    • Kathryn Mills
    • Jennifer Mueller
    • Carolyn Muller
    • David Mutch
    • Mario Javier Pineda
    • Allison Puechl
    • Lisa Rauh-Benoit
    • Bobbie Jo Rimel
    • Tyler Robin
    • Maria Rubinstein
    • Julian Schink
    • William Small
    • Jessica D. St. Laurent
    • Edward Tanner
    • Sarah Temkin
    • Tilley Jenkins Vogel
    • Aaron Wolfson
    • Catheryn Yashar

    Patient Representatives

    Dana Moore

    QOL Representative

    Elizabeth Jewell

    Medical Oncology Representative

    Martee Hensley


    >>>>>>>>>>>>>>>>
    Study Title Status Phase Disease Category Disease Site
    GOG-0184A RANDOMIZED PHASE III STUDY OF TUMOR VOLUME DIRECTED PELVIC PLUS OR MINUS PARA-AORTIC IRRADIATION FOLLOWED BY CISPLATIN AND DOXORUBICIN OR CISPLATIN, DOXORUBICIN AND PACLITAXEL FOR ADVANCED ENDOMETRIAL CARCINOMATerminatedIIIGynecologic [GY]Uterine Corpus
    NRG-GY032A Phase II Study of Tailored Adjuvant Therapy in POLE-Mutated and p53-wildtype/NSMP Early-Stage Endometrial Cancer (RAINBO BLUE & TAPER)

    Open to AccrualIIGynecologic [GY]Uterine Corpus
    NRG-GY031A Phase IB Study Of Combination Atr (M1774) And Bet Inhibition (Zen003694) To Exploit Arid1a Loss In Recurrent Ovarian And Endometrial Cancer

    Open to AccrualI/IIGynecologic [GY]Uterine Corpus
    NRG-GY028A Phase IB and Randomized Phase II trial of Megestrol Acetate with or without Ipatasertib in Recurrent or Metastatic Endometrioid Endometrial Cancer

    Open to AccrualI/IIGynecologic [GY]Uterine Corpus
    NRG-CC010A Phase III Trial of the Impact of Sentinel Lymph Node Mapping On Patient Reported Lower Extremity Limb Dysfunction in Endometrial Cancer

    Open to AccrualIIIGynecologic [GY]Uterine Corpus
    NRG-GY026A Phase II/III Study Of Paclitaxel/Carboplatin Alone Or Combined With Either Trastuzumab And Hyaluronidase-Oysk (Herceptin Hylecta) Or Pertuzumab, Trastuzumab, And Hyaluronidase-Zzxf (Phesgo) In Her2 Positive, Stage I-Iv Endometrial Serous Carcinoma Or Carcinosarcoma

    Open to AccrualII/IIIGynecologic [GY]Uterine Corpus
    NRG-GY025NRG-GY025: A RANDOMIZED PHASE II TRIAL OF NIVOLUMAB AND IPILIMUMAB COMPARED TO NIVOLUMAB MONOTHERAPY IN PATIENTS WITH DEFICIENT MISMATCH REPAIR SYSTEM RECURRENT ENDOMETRIAL CARCINOMA

    Open to AccrualIIGynecologic [GY]Uterine Corpus
    NRG-GY020A Phase III Randomized Trial of Radiation +/- Pembrolizumab (MK-3475) for Newly Diagnosed, Early Stage High Intermediate Risk Mismatch Repair Deficient (dMMR) Endometrioid Endometrial CancerClosed to AccrualIIIGynecologic [GY]Uterine Corpus
    NRG-GY018A PHASE III RANDOMIZED, PLACEBO-CONTROLLED STUDY OF PEMBROLIZUMAB (MK-3475, NSC #776864) IN ADDITION TO PACLITAXEL AND CARBOPLATIN FOR MEASURABLE STAGE III OR IVA, STAGE IVB OR RECURRENT ENDOMETRIAL CANCERClosed to AccrualIIIGynecologic [GY]Uterine Corpus
    GOG-0238A Randomized Trial of Pelvic Irradiation with or without Concurrent Weekly Cisplatin in Patients with Pelvic-only Recurrence of Carcinoma of the Uterine CorpusTerminatedIIGynecologic [GY]Uterine Corpus
    NRG-GY012A Randomized Phase II Study Comparing Single-Agent Olaparib, Single Agent Cediranib, and the Combinations of Cediranib/Olaparib, Olaparib/Durvalumab (MEDI4736), Cediranib/Durvalumab (MEDI4736), Olaparib/AZD5363 (Capivasertib) in Women with Recurrent, Persistent or Metastatic Endometrial Cancer.: A Platform Trial for Women with Recurrent or Persistent Endometrial CancerClosed to AccrualIIGynecologic [GY]Uterine Corpus
    GOG-0277A phase III randomized trial of gemcitabine (nsc# 613327) plus docetaxel (nsc#  628503) followed by doxorubicin (nsc# 123127) versus observation for uterus-limited, high-grade uterine leiomyosarcomaTerminatedIIIGynecologic [GY]Uterine Corpus
    NRG-GY008A Phase II Evaluation of Copanlisib BAY 80-6946 IND #130822, A Selective Inhibitor of PI3KCA, in patients with Persistent or Recurrent Endometrial Carcinoma Harboring PIK3CA Hotspot MutationsTerminatedIIGynecologic [GY]Uterine Corpus
    RTOG-1203A Randomized Phase III Study Of Standard Vs. IMRT Pelvic Radiation For Post-Operative Treatment Of Endometrial And Cervical Cancer (TIME-C)--RTOG CCOP StudyTerminatedIIIGynecologic [GY]Other
    NRG-GY011A Randomized Surgical Window Pilot Investigation of the Relationship of Short Term Medroxyprogesterone Acetate (NSC #26386) Compared to Medroxyprogesterone Acetate Plus Entinostat (NSC #706995) on the Morphologic, Biochemical, and Molecular Changes in Primary Endometrioid Adenocarcinoma of the Uterine CorpusTerminatedIGynecologic [GY]Uterine Corpus
    GOG-0286BA Randomized Phase II/III Study of Paclitaxel/Carboplatin/Metformin (NSC#91485) Versus Paclitaxel/Carboplatin/Placebo as Initial Therapy for Measurable Stage III or IVA, Stage IVB, or Recurrent Endometrial CancerClosed to AccrualII/IIIGynecologic [GY]Uterine Corpus

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