The seven cancer disease site committees are the units within which most research protocols are developed and executed. Disease site committee chairs and co-chairs have in depth experience in the development and conduct of clinical trials, are engaged in national and international research networks, and have extensive publication track records. They are responsible for developing both long- and short-term strategic research plans for common and rare malignancies in their domain and for presenting these visions to NRG Oncology’s Research Strategy Committee.