Phase III Trial of Stereotactic Radiosurgery (SRS) or Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) for Distant Brain Relapse With Brain Metastasis Velocity ≥4 Brain Metastases/Year
Principal Investigator
Vinai Gondi, MD
Status
Terminated
Date Opened To Accrual
December 15 2020
Date Closed to Accrual
August 06 2024
Date of Study Termination
August 06 2024
Disease Site
Brain [BN]
Other
Phase
III
Developmental Therapeutics
No
Primary Objective
To determine if hippocampal-avoidantwhole brain radiotherapy (HA-WBRT) in patients with distant brain failure withbrain metastasis velocity ≥4 new brain metastases/year prolongs time toneurologic death as compared to stereotactic radiosurgery (SRS).
Patient Population
Distantbrain relapse with brain metastasis velocity ≥4 brain metastases/year sincelast SRS
Target Accrual
350